Fig. 2

The potentiation of the anticancer effect of vincristine by FW-04-806 in the KBv200 cell xenograft nude mice model. a The tumor growth curve was drawn according to the tumor volume and day after treatment. Data shown are mean ± SD of tumor volume for each group (n = 8). b The image of tumors size in four groups excised from the mice on the 28th day after implantation. c Animals’ body weights were measured every 3 days, and the average percentage change was calculated. d The average tumor weight of each group was calculated after the tumors excised from the mice. The four treatment groups were: (1) saline (i.g., every 3 day); (2) vincristine (0.5 mg/kg, i.v., every 3 day); (3) FW-04-806 (100 mg/kg, i.g., every 3 day); (4) FW-04-806 (100 mg/kg, i.g., every 3 day, given 1 h before vincristine administration) plus vincristine (0.5 mg/kg, i.v., every 3 day). Data shown are mean ± SD for each group; ^* P < 0.05