Fig. 2

Podocyte-specific loss of PP2A leads to proteinuria and renal dysplasia. a Compared with the control, the Pod-PP2A-KO mice fail to gain weight at 6 weeks of age. n = 10 mice.* P < 0.05, **P < 0.001. b Representative images of the control mice and Pod-PP2A-KO mice at 12 weeks of age. c Representative images of kidney from control and Pod-PP2A-KO mice at 12 weeks of age. The kidney from the Pod-PP2A-KO mice was smaller than that of control, even after the size of kidney was balanced by the size of body. d Survival curve of Pod-PP2A-KO mice demonstrates greater than 50% death at 12 weeks of age. n = 10 mice. e SDS-PAGE (Coomassie blue staining) of urine from Pod-PP2A-KO mice, demonstrating albuminuria at 3, 5 and 8 weeks of age. 2 μl of standard BSA and urine were loaded in each lane. f Quantification of urinary albumin normalized to creatinine at 3, 4, 6, and 8 weeks of age. n = 8 mice