Fig. 4

a Quantification of Ki67 labeling indices in three allografted tumor lines. b Quantification of TUNEL labeling indices in the same tumor lines. ****, p-value≤0.0001 for comparisons of recombined Erbb4 allele (erbB4 -) grafts to grafts with non-recombined Erbb4 alleles (erbB4+). c-i Representative CD31 staining of control erbB4 positive tumors (c, e) and erbB4 negative tumors (g, i) with Bisbenzimide counterstain (b, h) for cell nuclei detection. A non-immune isotype matched primary was used as a negative control (f). Images were acquired at 40X. Scale bars represent 100 um. j Quantification of representative immunofluorescent images using FIJI. *, p-value≤0.05; ****p-value≤0.0001 for comparisons of recombined (Erbb4 -) with non-recombined (Erbb4+) alleles