Fig. 6
From: mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
The effect of rapamycin administration on the expression of HIF1α, VEGFA, VEGFR1/2, and mTOR-related proteins detected by Western blot. a – Expression of indicated proteins. b, c – Comparison of expression of p-mTOR S2448 and S2481 relative to total mTOR levels in NR and RPE/Choroid. Data are presented as the mean ± S.E.M. d, e – relative expression of the pS6 ribosomal protein and pAKT (S473) normalized to β-actin. Data are presented as the mean ± S.E.M. * P < 0.05, Mann-Whitney U test, compared with Normal group. # P < 0.05, Mann Whitney U test, compared with the 5dRapa(−) group. + P < 0.05, Mann Whitney U test, compared with 5dRapa(+) group. - P < 0.05, Mann Whitney U test, compared with the 12dRapa(−) group. @ p < 0.05, Mann Whitney U test, compare with 12dRapa(+) group