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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization

Fig. 5

KBP stimulates M1 polarization in vitro. The mRNA expression levels of different markers/cytokines of M1 or M2 macrophages were measured, and the M1/M2 ratio was calculated. a The M1/M2 ratio in THP-1 cells. b The M1/M2 ratios of different groups in RAW264.7 cells. c The M1/M2 ratios of different groups in BMDMs. d The levels of type-1 immune cytokines (TNFα and IL-6) in the supernatants of different groups of RAW264.7 cells. e-g Western blot to detect iNOS and ARG1 in THP-1 cells, RAW264.7 cells and BMDMs together with a greyscale histogram. Data are presented as the mean ± SD. n = 3; * p < 0.05

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