Fig. 1
From: Neuropilin-1 drives tumor-specific uptake of chlorotoxin
Structure of Cltx, ER-472 and related compounds. a, amino acid sequence of native Cltx which features 4 disulfide bonds, 3 lysine (K) and 3 arginine (R, in bold) residues, including amidated R at the C-terminus. b, structure of ER-472 PDC comprised of Cltx peptide linked via K27 to a novel cryptophycin analog (cytotoxic warhead), via a cleavable dimethyl disulfide linker. c, S-methyl cryptophycin, the active metabolite of ER-472 generated in tumor. d, ER-271 mimics ER-472 that lacks Cltx; composed of cryptophycin analog plus the dimethyl disulfide linker which terminates in an aryl group