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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways

Fig. 2

Ori enhanced Nrf2 signaling pathway in a dose- and time-dependent manner in RAW 264.7 cells. a and d RAW 264.7 cells were treated with different concentrations of Ori (2.5, 5 or 10 μM) for 6 h, or (f and h) cells were exposed to Ori (10 μM) for three time points (1, 3, 6 h). Protein expressions were measure by Western blot analysis. b, c, e, g and i Quantification of protein expressions were performed by densitometric analysis, and β-actin acted as an internal control for total or cytoplasmic proteins and Lamin B for nuclear proteins. All of the data shown represent the average from three independent experiments. *p < 0.05 and **p < 0.01 versus the control group

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