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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway

Fig. 2

Activin A induces myofibroblast differentiation of endometrial MSCs. Eutopic endometrial MSCs derived from patients without endometriosis (n = 3) were treated with 25 ng/mL Activin A for indicated time (a) or with indicated concentration of Activin A for 3 h (b). mRNA expression levels of ACTA2, COL1A1, CTGF and FN1 were analyzed by q-PCR. The data were presented as means ± SD. **P < 0.01 and ***P < 0.001 versus the cells treated without Activin A, respectively. Eutopic endometrial MSCs derived from patients without endometriosis (n = 3) were treated with 25 ng/mL Activin A for indicated time (c) or with indicated concentration of Activin A for 6 h (d). The protein expression of α-SMA, collagen I, CTGF and fibronectin were was analyzed by Western blot. The expression levels of proteins were quantified by densitometry and normalized to the expression of GAPDH. *P < 0.05 and ***P < 0.001 versus the cells treated without Activin A, respectively

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Cell Communication and Signaling

ISSN: 1478-811X