Fig. 4

Effect of the p38 inhibitor on endothelial resistance and IP-10 production: a HMVECs were grown on transwells for 24 h then given SB203580 (10 μmol/L) or vehicle control (DMSO < 0.1%). 30 min later cells were exposed to Poly I:C (10 μg/mL) or control and TEER was recorded for every hour for 16 h afterwards and normalized to resistance 1 h prior to SB203580. b Associated AUC for duration of the TEER experiment in A. c IP-10 production as measured by ELISA for HMVECs exposure to combinations of SB203580 and Poly I:C at the time and concentrations previously stated (n = 4 replicates per group). * = p < 0.05 between compared groups, NS = non-significant