Fig. 2

Under pathologic circumstances, pericytes present stemness or trans-differentiation potential. Brain injury induces pericytes to leave capillary and achieve microglial phenotype while pericyte marker expression retains. After ischemic stroke, the suppression of the pericytes aPKC-CBP signaling pathway contributes in reemergence of induced neural precursors markers 3 days post-stroke. However, iSCs generation in ischemic regions pericytes is plausible by co-expressing MSCs, Neural stem/progenitor cells, and vascular lineage markers along with pericytes markers. Utilization of neural- or endothelial-conditioned medium on iPCs culture in vitro leads to neural or vascular lineage generation