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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer

Fig. 2

Mesenchymal NSCLC upregulate enzymes involved in the synthesis of UDP-GlcNAc. a Immunoblotting of total cell lysates demonstrates an increase in O-GlcNAcylation following TNF and TGFβ stimulation of 3D NSCLC cultures without notable changes in OGT or OGA protein levels. Densitometry analysis of immunoblots were used to determine the fold changes in O-GlcNAc levels relative to the GAPDH loading control. Asterisks mark the bands used for densitometric analysis to calculate the fold change (FC). b Venn diagram illustrating the overlap between genes upregulated in mesenchymal A549 cells (green) with the total number of metabolic genes in human genome (blue). Analysis identified 97 metabolic genes specifically upregulated in mesenchymal A549 cells. FDR < 0.05

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Cell Communication and Signaling

ISSN: 1478-811X