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Fig. 13 | Cell Communication and Signaling

Fig. 13

From: Regulation of platelet-activating factor-induced interleukin-8 expression by protein tyrosine phosphatase 1B

Fig. 13

PTP1B modulates IL-8 production via a SFK-Akt-GSK-3-C/EBPß pathway. In iMo-DCs, PAF fine-tunes IL-8 production by activating PTP1B [63] which in turn activates SFK. This PTP1B/SFK signaling pathway up-regulates the phosphorylation of the residues Ser21 of GSK-3α and Ser9 of GSK-3ß, decreasing the capacity of these kinases to phosphorylate their substrates. Whereas the PI3K-Akt pathway mediates the PTP1B/SFK effects on GSK-3 phosphorylation at later stimulation times, the exact mechanism by which the PTP1B/SFK signaling pathway modulates GSK-3 phosphorylation at early stimulation times remains to be identified. These increased GSK-3 phosphorylation levels result in a lower pThr235 C/EBPß and lower IL-8 production

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Cell Communication and Signaling

ISSN: 1478-811X