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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells

Fig. 8

Oroxylin A inhibits HSC glycolysis by targeting LDH-A in mice intoxicated with CCl4. Animal grouping and treatments refer to the Methods section. a Measurements of hepatic lactate levels. b Real-time PCR analyses of mRNA expression of HK2, PFK1, PKM2 and LDH-A in liver tissues. c Western blot analyses of protein expression of HK2, PFK1, PKM2 and LDH-A in liver tissues with quantification. d, e Immunofluorescence analyses of HK2, PFK1, PKM2, and LDH-A in liver tissues. Staining with α-SMA was used to indicate HSCs, scale bar: 20 μm. For statistical significance of this figure: **p < 0.01 vs. control, ***p < 0.001 vs. control; ##p < 0.01 vs. CCl4; &p < 0.05 vs. CCl4 + oroxylin A + adenovirus vector, &&p < 0.01 vs. CCl4 + oroxylin A + adenovirus vector

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Cell Communication and Signaling

ISSN: 1478-811X