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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling

Fig. 3

Memantine co-treatment augments inhibition of AKT, ERK1/2 and MYC signaling. a. and b. Jurkat cells were cultured without drug, with 100 μM memantine, 60 nM AraC, and memantine+AraC for 72 h (lanes 1–4, respectively). a Cytoplasmic and b nuclear protein samples were immunoblotted for expression of the indicated proteins; ß-Actin and Lamin B expression served as control for protein loading. A representative Western blot is shown for each indicated protein. The data in bar graphs provide the mean + SD relative expression of the indicated protein calculated from densitometric quantifications of n = 3–4 independent experiments for each indicated protein

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