Fig. 7

Protective effects of Cori treatment on APAP-induced ALI. a Experimental protocol for APAP-induced ALF model, Cori (15, 30 or 60 mg/kg) was administered intraperitoneally to mice for twice at a 12 h (interval for 12 h), followed by subjected treatment with APAP (900 mg/kg). The survival rates of the mice (n = 15/group) were observed within 48 h after APAP exposure. b-c Sera were collected from the mice after exposure to APAP (400 mg/kg) for 6 h for measurement of the ALT and AST levels. d Representative histological sections of the livers were stained with hematoxylin and eosin (H & E)-stained (magnification × 400). Similar results were obtained from three independent experiments. All data are presented as means ± SEM (n = 5/group). ^##p < 0.01 vs. Control group; ^*p < 0.05, ^**p < 0.01 vs. APAP group