Fig. 7
From: C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation
C3G increases platelet production in response to TPO. Mice were injected intravenously with 5 μg TPO/mouse and blood samples were collected at the indicated time points. a Time course of platelet counts in Tg-C3G (left panel), Tg-C3GΔCat (right panel) and their corresponding wild-types. The graphs represent the median of the number of platelets (1000/μl) of each phenotype. b The histograms represent the mean ± SEM of the maximum fold change in the number of platelets in blood after TPO treatment (platelet count at day 5–6 /platelet count at day 0)