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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Regulation of MRTF-A by JMY via a nucleation-independent mechanism

Fig. 3

Reduced MRTF-SRF activation by JMY upon fusion to a nuclear localization signal (NLS). a: NIH 3 T3 mouse fibroblasts were transfected with the indicated JMY constructs, with and without a NLS fused to the N-terminus, and analyzed for MRTF-SRF activation under serum-starved conditions. b: Expression of myc-tagged (NLS-) JMY variants was controlled by immunoblotting with myc-specific antibody and tubulin as a control. Data are normalized to induction by JMY full length. Error bars, s.e.m., n = 5 (* p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 according to an unpaired two sample student’s t-test)

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