Fig. 3

Culture condition-specific physiological response of yeast cells to long-term rapamycin exposure. Physiological parameters that showed a significant difference in response to sustained rapamycin exposure in either one or more sets of culture conditions; air+pH+, air+pH-, air-pH+, and air-pH-, are displayed. (a) depicts the responses that become higher or faster in response to rapamycin exposure and (b) depicts those that are slowed down or lower than those for untreated controls. For colour coding in (a) and (b), see legend for Fig. 2. c denotes the amino acids, which display a significant change in the given culture conditions. Deeper shades denote a significant change and pale colours signify that there is no difference. The amino acids are colour-grouped into families that are derived from common molecules; shades of blue denote the aspartate family, shades of green denote the serine family, shades of red denote the glutamate family, shades of ochre denote histidine, shades of grey denote the pyruvate family, and the shades of purple denote the aromatic family