Fig. 6

Schematic model of p130Cas-dependend alterations in skin homeostasis. p130Cas loss in basal keratinocytes leads to an alteration in integrin and cadherin adhesive platforms, reflected by reduced ECM attachment and aberrant formation of cell-cell junctions. These signaling hubs are important regulators of p63 and YAP, key determinants of keratinocyte commitment to differentiation. Consistently, epidermal p130Cas loss induces an amplification of premature differentiation-committed keratinocytes characterized by increased proliferation, reduced basal p63 expression and ectopic suprabasal YAP nuclear localization. The altered balance between keratinocyte proliferation and differentiation promotes epidermal thickening in mutant mice