Fig. 4From: Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal glandActivation of MAPKs and PI3K/Akt pathways and increased proliferation, and resistance to apoptosis occurred in BLEL. (a) Representative western blot results of MAPKs and PI3K/Akt phosphorylation status are shown. (b) Representative western blot results of apoptosis and proliferation markers are shown. (c) Immunostaining performed for the proliferation marker Ki-67 are shown (CH: n = 4; BLEL: n = 4). (d) Representative images of TUNEL DNA fragmentation assay performed on tissue biopsies of 5 CH and 5 BLEL specimens. Arrowheads in BLEL panel indicated the only few apoptotic cells. (c and d) Original magnification: 40×Back to article page