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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland

Fig. 4

Activation of MAPKs and PI3K/Akt pathways and increased proliferation, and resistance to apoptosis occurred in BLEL. (a) Representative western blot results of MAPKs and PI3K/Akt phosphorylation status are shown. (b) Representative western blot results of apoptosis and proliferation markers are shown. (c) Immunostaining performed for the proliferation marker Ki-67 are shown (CH: n = 4; BLEL: n = 4). (d) Representative images of TUNEL DNA fragmentation assay performed on tissue biopsies of 5 CH and 5 BLEL specimens. Arrowheads in BLEL panel indicated the only few apoptotic cells. (c and d) Original magnification: 40×

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