Fig. 4
From: Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration
Pharmacological inhibition of LSD1 reduces cell migration of SHH MB cell lines. a, Scratch wound migration assay of UW228 and Daoy cells at low dose (5 uM) and high dose (75 uM) of GSKLSD1. b, Scratch wound migration assay of UW228-REST and Daoy-REST cells at low dose (5 uM) and high dose (75 uM) of GSKLSD1 (*p < 0.05, **p < 0.01). UW228-REST and Daoy-REST cells migrate twice as fast as UW228 and Daoy cells, respectively (p < 0.05). c, Transwell migration of Daoy and Daoy-REST cells over 24 h at 75 uM of GSKLSD1. Slope of migration is significantly reduced (p < 0.05)