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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer

Fig. 4

KLF4 promoted cisplatin-induced apoptosis via regulating BIK. a-d PC3 and DU145 cells with or without BIK knockdown were treated with 20 μM cisplatin for the indicated times. Cell apoptosis was detected by western blotting and cell viability was measured by a CCK8 assay. Data represent the mean ± SD of three independent experiments. **p < 0.01 vs. control. e-h Flag-BIK was transfected into PC3 and DU145 cells with or without KLF4 knockout and then the cells were treated with 20 μM cisplatin at the indicated times. Cell apoptosis was detected by western blotting and cell viability was measured by a CCK8 assay. Data represent the mean ± SD of three independent experiments. **p < 0.01 vs. control

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