Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels

Table 1 Association between RHBDD1 expression and clinicopathologic parameters in 116 breast cancer patients

Clinicopathologic parameters	N	RHBDD1		p-value
Clinicopathologic parameters	N	Weak (IHC Score < 5)	Strong (IHC Score ≥ 5)	p-value
Age				0.6357
≤ 50	58	12	46
> 50	58	10	48
Differentiation				0.2066
Low	7	3	4
Moderate	106	19	87
High	3	0	3
pTNM				0.01474*
I	6	3	3
II	67	8	59
III	39	11	28
pT				1.165e-13*
T1	24	6	18
T2	79	13	66
T3	12	2	10
pN				0.1734
N0	41	7	34
N1	35	4	31
N2	28	8	20
N3	8	3	5
ER				0.04679*
Negative	42	12	30
Positive	74	10	64
PR				0.2443
Negative	50	12	38
Positive	65	10	55
HER2				0.7027
Negative	88	16	72
Positive	28	6	22

pTNM pathological tumor-node-metastasis, pT pathological tumor, pN pathological node
The significance of RHBDD1 expression in clinicopathologic parameters was analyzed by Pearson’s chi-squared test. If the expected counts were less than 5, Fisher’s exact test was used to analyze the statistics (* p < 0.05)

ISSN: 1478-811X