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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Regulation of the master regulator FOXM1 in cancer

Fig. 4

Schematic diagram of FOXM1 regulation network. This schematic diagram attempts to address the regulation of FOXM1 in a spherical way. Green: promotion of FXOM1 expression or transcriptional activity; Red: repression of FOXM1 expression or transcriptional activity. .Transcriptional regulation of FOXM1: iTF (inhibitory transcription factor) binds to the promoter region of FOXM1 and inhibits its transcription. aTF (activating transcription factor) binds to the promoter region of FOXM1 and enhances its transcription. .Post-transcriptional regulation of FOXM1: m6A methylation of FOXM1 pre-mRNA and the miRNAs binding to 3′UTRs of FOXM1 mRNA and guiding FOXM1 are listed. lncRNAs can act as ceRNAs and block the suppression of FOXM1 by miRNAs. . Protein/RNA directly interacts with FOXM1 protein: The interaction of protein/RNA with FOXM1 protein alter the cellular localization, stabilization, or transcriptional activity of FOXM1. . Post-translational modifications of FOXM1 protein

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