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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Regulation of the master regulator FOXM1 in cancer

Fig. 4

Schematic diagram of FOXM1 regulation network. This schematic diagram attempts to address the regulation of FOXM1 in a spherical way. Green: promotion of FXOM1 expression or transcriptional activity; Red: repression of FOXM1 expression or transcriptional activity. ①.Transcriptional regulation of FOXM1: iTF (inhibitory transcription factor) binds to the promoter region of FOXM1 and inhibits its transcription. aTF (activating transcription factor) binds to the promoter region of FOXM1 and enhances its transcription. ②.Post-transcriptional regulation of FOXM1: m6A methylation of FOXM1 pre-mRNA and the miRNAs binding to 3′UTRs of FOXM1 mRNA and guiding FOXM1 are listed. lncRNAs can act as ceRNAs and block the suppression of FOXM1 by miRNAs. ③. Protein/RNA directly interacts with FOXM1 protein: The interaction of protein/RNA with FOXM1 protein alter the cellular localization, stabilization, or transcriptional activity of FOXM1. ④. Post-translational modifications of FOXM1 protein

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Cell Communication and Signaling

ISSN: 1478-811X