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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Chemotherapy induced PRL3 expression promotes cancer growth via plasma membrane remodeling and specific alterations of caveolae-associated signaling

Fig. 6

PRL3 expression affects cellular growth-associated signaling (a) Rac1-GTP loading increases upon PRL3 expression. b AKT phosphorylation increases at Ser473 upon PRL3 expression. c GSK phosphorylation increases at Ser9 upon PRL3 expression. d Cyclin D1 levels are upregulated upon PRL3 expression. e Representative confocal images of the localization of cyclin D1 in the indicated cells. Cyclin D1 localizes to the nucleus. f Rac1 inhibition decreases the elevated cyclin D1 levels. The indicated cells were treated with 10 μM NSC23766 for 24 h in order to inhibit Rac1-dependent elevation of cyclin D1 levels

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Cell Communication and Signaling

ISSN: 1478-811X