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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Chemotherapy induced PRL3 expression promotes cancer growth via plasma membrane remodeling and specific alterations of caveolae-associated signaling

Fig. 2

PRL3 contributes to tumorigenic growth. a PRL3 expression in B16F0 cells artificially expressing (human) PRL3, either in a constitutive or in a conditional (doxycycline-induced) manner. b Growth of B16F0 cells in anchorage-independent conditions. The indicated B16F0 cells were seeded into agar-containing media and cultured for 14 days. Colony formation from single cells was assessed by measuring cell viability with a resazurin-based Alamar blue assay (n = 3, SEM). * p ≤ 0.005 tested by Student t-test. c Tumor volume changes of subcutaneously injected B16F0 cells in mice. The indicated cells were injected subcutaneously into C57BL/6 J mice (n = 6, SEM). * p ≤ 0.05 tested by Aspin-Welch t-test. The volumes of the tumors were measured at the indicated time points

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Cell Communication and Signaling

ISSN: 1478-811X