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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1

Fig. 6

HSF1 overexpression promotes proliferation and inhibits apoptosis of HCC cells. (a) CCK8 assay shows proliferation of HepG2 and SMMC-7721 cells co-transfected with miR-644a mimic and wild-type or mutant HSF1 (wild type or mutant 3’UTR). (b) Colony formation assay shows the total number of colonies in HepG2 and SMMC-7721 cells co-transfected with miR-644a mimic and wild-type or mutant HSF1. (c) Flow cytometry analysis of percent apoptosis (AnnexinV+ PI+) in HepG2 and SMMC-7721 cells co-transfected with miR-644a mimic and wild-type or mutant HSF1. Note: * denotes P < 0.05 and ** denotes P < 0.01 compared to controls

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Cell Communication and Signaling

ISSN: 1478-811X