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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Disrupting SOD1 activity inhibits cell growth and enhances lipid accumulation in nasopharyngeal carcinoma

Fig. 2

Knockdown of SOD1 expression in NPC cells inhibits cell viability and induces apoptosis. a Immunoblotting analysis of SOD1 in 5-8F and CNE2 cells transfected with two specific siRNAs or control siRNA. b and c Analysis of cell viability and clonogenicity in 5-8F and CNE2 cells with SOD1 knockdown. d Analysis clonogenicity in 5-8F and CNE2 cells with SOD1knocked down. e 5-8F and CNE2 cells were transfected with SOD1 plasmids and vector. f Clonogenicity of 5-8F and CNE2 cells with SOD1overexpression. g Cell apoptosis was measured by Annexin-V/PI assays in control cells and cells with SOD1 knockdown for 48 h. h Cell apoptosis was measured in SOD1-overexpressing and vector cells treated with PMS (25 μM) for 48 h. All error bars represent the S.D. of at least three replicates from two independent experiments.*p < 0.05, **p < 0.01 for the indicated comparison

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Cell Communication and Signaling

ISSN: 1478-811X