Skip to main content
Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6

Fig. 6

HDAC8 alters Alpha tubulin Functionality. a Cell Migration Assay in HeLa cells in absence or presence of PCI-34051 (10 μM) or Paclitaxel (10 μM) Migration efficiency: Control> > Paclitaxel>PCI-34051. b Cell Migration Assay in HeLa cells in absence or presence of PCI-34051 (20 μM) or Paclitaxel (20 μM). c Cell morphology analysis demonstrating reduced (shrinking) cell size of HeLa with PCI-34051 (20 μM) or Paclitaxel (20 μM) at 24 & 48 h. d Cell morphology analysis in HEK 293 T cells representing clump formation with PCI-34051 (20 μM) or Paclitaxel (20 μM) at 24 & 48 h signifying role of HDAC8 in microtubule organization. e Cell cycle analysis of HeLa, showing (I) control, (II) PCI-34051 (20 μM) and (III) Paclitaxel (20 μM) treated condition. f Graphical representation of subG0, G0/G1, S and M phase in HeLa, deciphering significant effect of PCI-34051(20 μM) on Mitotic phase. * indicates p-value < 0.05

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X