Table 1 Hedegehog Pathway Inhibitors
| Â | Compound | Where it acts |
|---|---|---|
Biological-based inhibitors | 3H8, 6D7 (antibody) | Shh pathway inhibitor |
Cyclopamine | Smo inhibitor | |
5E1 Antibody | Shh pathway inhibitor | |
Isoflavon (Genistein) | Shh pathway inhibitor | |
Curcumin | Gli 1 inhibitor | |
Resveratrol | Gli 1 inhibitor | |
Epigallocatechin-3-gallate | Gli 1 inhibitor | |
Physalin B and Physalin F | Gli 1 inhibitor | |
Jervine | Smo inhibitor | |
Zerumbone | Gli 1 inhibitor | |
Staurosporinone | Gli 1 inhibitor | |
Vitamin D3 | Smo inhibitor | |
Chemical Based | GDC-0449 (Vi sm odegib/Erivedgeâ„¢) | Smo inhibitor |
IPI-926 (Saridegib) | Smo inhibitor | |
NVP-LDE225 (Erismodegib) (Sonidegib) | Smo inhibitor | |
PF-04449913 (Glasdegib) | Smo inhibitor | |
BRD-6851 | Smo inhibitor | |
LY2940680 | Smo inhibitor | |
MK-5710 | Smo inhibitor | |
SEN450 | Smo inhibitor | |
PF-5274857 (A-116) | Smo inhibitor | |
MRT-10 and MRT-14 | Smo inhibitor | |
TAK-441 | Smo inhibitor | |
SANT1, SANT2, SANT3, SANT4, SANT74 and SANT75 | Smo inhibitor | |
MS-0022 | Smo inhibitor | |
Arsenic Trioxide (ATO) | Gli 1 inhibitor | |
Sodium Arsenite | Gli 1 inhibitor | |
HPI-1, HPI-2, HPI-3 and HPI-4 | Gli inhibitors | |
AKI0532 | Probably Smo inhibitor | |
Itraconazole | Smo inhibitor | |
GANT 58, GANT 61 | Gli 1 inhibitor | |
KAAD-Cyclopamine | Smo inhibitor | |
Cur-61,414 | Smo inhibitor | |
Robotnikinin | Shh pathway inhibitor | |
SAG | Smo inhibitor | |
Purmorphamine | Smo inhibitor | |
BMS-833923 (XL139) | Smo inhibitor | |
LY2940680 (Taladegib) | Smo inhibitor | |
MRT-92 | Smo inhibitor | |
PF-5274857 | Smo inhibitor | |
LEQ506 | Smo inhibitor | |
RU-SKI 43 | Shh pathway inhibitor | |
Imiquimod | Shh pathway inhibitor | |
Patidegib | Shh pathway inhibitor |