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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer

Fig. 4

Effects of HMGB2 on aerobic glycolysis in breast cancer cells in vitro. a Silencing HMGB2 expression in MDA-MB-231 and MCF-7 cells significantly decreased glucose utilization and lactate production. Glycolysis is a multi-step enzymatic reaction involving with a series of rate-limiting enzymes, (b) Heatmap of differentially expressed glycolytic enzymes genes in HMGB2 knockdown breast cancer cells using qRT-PCR with results normalized by Z-score. Each column represents a specimen, denoted above, and each role represents a gene, which is denoted on the right. Red color indicates genes that were upregulated and green color indicates genes that were downregulated. Results were further validated by RT-PCR (c) and Western blot (d) in HMGB2 stable knockdown cells

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Cell Communication and Signaling

ISSN: 1478-811X