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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model

Fig. 1

AMAP1 is differentially expressed in tumors from MMTV-PyMT and MMTV-Neu mice. a Primary tumors or lung-metastasized tumors from PyMT mice (12–20 weeks old) or Neu mice (40–56 weeks old) were subjected to immunoblot analysis with the indicated antibodies. b Quantitative western blots of Arf6, AMAP1, GEP100, and γ-tubulin in primary tumors were performed using an infrared fluorescence imaging system on Odyssey imager (normalized to γ-tubulin). Bars represent means ± SE. ****P < 0.0001 (Student t-test); n.s., not significant. c Primary tumors from PyMT mice (12–20 weeks old) or Neu mice (40–56 weeks old) were subjected to semi-quantitative RT-PCR analysis with the primers for the indicated genes. d The public microarray datasets of PyMT- or Neu-tumor cells (GSE3165) were examined using the GEO2R tool. Amap1 mRNA levels in these cells are shown. Bars represent means ± SE. *P < 0.05 (Student t-test)

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Cell Communication and Signaling

ISSN: 1478-811X