Fig. 1

Model schematic of TSP1-mediated apoptosis signaling. TSP1 binding to the CD36 receptor recruits p59fyn, which induces activation of the caspase-3 cascade. The kinase p38MAPK is subsequently phosphorylated and translocated to the nucleus. NF-κB translocates into the nucleus and is activated in the presence of phosphorylated p38MAPK. This leads to transcriptional activation of FasL. FasL protein binds to its receptor Fas, forming the DISC complex, which binds to c-FLIP (FL) and procaspase-8 (pro8) to form the p43-FLIP complex. This complex activates IKK, which releases NF-κB from its inhibitor IκB. Blue arrows indicate transport reactions