Fig. 1
From: Adaptive phenotype drives resistance to androgen deprivation therapy in prostate cancer
Characterization of PDB and MDB cell sublines. a Using phase contrast microscopy PDB and MDB cells show a morphology different from parental LNCaP cells: they are more rounded with a significantly smaller area. Horizontal lines indicate the mean values obtained by measuring at least 250 cells (right panel). b Cell Proliferation curves in the absence or presence of 10 μM BIC (PDB and MDB) compared to LNCaP parental cells. c Dose-response for DHT in LNCaP, PDB and MDB. The cells were treated for 3 days with the indicated concentration of DHT