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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4

Fig. 4

Studies on prominent biomarkers for prostate carcinogenesis AMACR and GSTP1. a Gene expression analyses of alpha-methylacyl-CoA racemase (AMACR) did not show significant differences between TUR-BPH, RP-BPH and RP-PCa; b A significantly increased GSTP1 promoter methylation was observed by quantitative methylation specific PCR in RP-BPH and RP-PCa in comparison to TUR-BPH; c The Spearman’s correlation test considering all prostate tissue samples revealed a highly significant negative correlation between GSTP1 promoter methylation and IGF2-DMR0 methylation; d Methylation levels in IGF2/H19-ICR and in GSTP1 promoter were not correlated. Spearman’s rank correlation coefficients r and p-values are indicated

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