Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice

Table 1 Physiological parameters from mice fed control or Mg²⁺-deficient diet

	Day 7		Day 14		Day 21		Day 28
	0.05% Mg²⁺	0.003% Mg²⁺	0.05% Mg²⁺	0.003% Mg²⁺	0.05% Mg²⁺	0.003% Mg²⁺	0.05% Mg²⁺	0.003% Mg²⁺
Bodyweight, g	20.5 ± 0.38	20.9 ± 0.60	20.3 ± 0.50	21.6 ± 0.38	21.6 ± 0.19	22.1 ± 0.19	23.2 ± 0.79	23.1 ± 0.94
Urine, ml/24 h	1.8 ± 0.18	1.1 ± 0.011*	1.7 ± 0.38	0.7 ± 0.05**	1.5 ± 0.25	1.1 ± 0.19	1.9 ± 0.16	0.9 ± 0.27*
Feces, g/24 h	0.17 ± 0.017	0.09 ± 0.013**	0.20 ± 0.015	0.11 ± 0.008***	0.22 ± 0.012	0.11 ± 0.017**	0.22 ± 0.013	0.12 ± 0.015**

Mice were fed the control (0.05% Mg²⁺) or Mg²⁺-deficient (0.003% Mg²⁺) diet and sacrificed on 7, 14, 21 and 28 days. Mice were transferred to metabolic cages for 24 h. Bodyweight, excreted feces and urine per 24 h were measured. Results are displayed as mean ± S.E.M
*p < 0.05
**p < 0.01
*** p < 0.001 vs. 0.05% Mg²⁺ diet. n = 3–6

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