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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Fibroblast growth factor 2 supports osteoblastic niche cells during hematopoietic homeostasis recovery after bone marrow suppression

Fig. 6

FGF2 increase, ERK pathway activation, and the expansion of endosteal osteoblast population following 5FU treatment. a Immunohistochemical staining on the bone marrow of mice 3 days after 5FU treatment. Bone section counterstained with methyl green. Magnification ×100. b Total proteins were extracted at 3 and 6 days after 5FU treatment in endosteal OBs from PBS- or 5FU-treated mice. pERK and ERK expression was analyzed by western blotting. c Representative H&E stained sections of tibiae at 3 and 6 days following 5FU treatment in mice. Endosteal OBs showed increased cellularity along the endosteal surface at the indicated time points. Arrows indicates multilayer cuboidal osteoblast on the trabecular bone

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