Skip to main content


Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Fibroblast growth factor 2 supports osteoblastic niche cells during hematopoietic homeostasis recovery after bone marrow suppression

Fig. 6

FGF2 increase, ERK pathway activation, and the expansion of endosteal osteoblast population following 5FU treatment. a Immunohistochemical staining on the bone marrow of mice 3 days after 5FU treatment. Bone section counterstained with methyl green. Magnification ×100. b Total proteins were extracted at 3 and 6 days after 5FU treatment in endosteal OBs from PBS- or 5FU-treated mice. pERK and ERK expression was analyzed by western blotting. c Representative H&E stained sections of tibiae at 3 and 6 days following 5FU treatment in mice. Endosteal OBs showed increased cellularity along the endosteal surface at the indicated time points. Arrows indicates multilayer cuboidal osteoblast on the trabecular bone

Back to article page