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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling

Fig. 1

Expression of ARC in clear cell RCCs and RCC cell lines. a ARC was strongly overexpressed in the cytoplasm of clear cell RCCs (1) compared to non-neoplastic renal tissue (2), as determined by immunohistochemistry. Furthermore, nuclear ARC expression was only detectable in RCCs and not in non-neoplastic tissue. For semiquantitative analysis of ARC expression cytoplasmatic stainig was scored from 0 to 12 and nuclear expression was scored from 0 to 4. All values are expressed as the mean ± s.d. *p < 0.05. b ARC was also strongly expressed in the cytoplasm and nucleus of the RCC cell lines clearCa-6, −3 and −12. Nuclear and cytoplasmic distribution of ARC differed only slightly between the three RCC cell lines, as determined by fluorescent immunohistochemistry

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Cell Communication and Signaling

ISSN: 1478-811X