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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation

Fig. 4

Taxonomy of retrotransposons. The so-called retrotransposons or class I transposons as opposed to class II (DNA) transposons (not depicted) can be grouped into long terminal repeat (LTR) containing and non-LTR transposons. The best investigated LTR retrotransposons are the human endogenous retroviral elements (ERV). Together with the non-LTR retrotransposons LINE (long interspersed nuclear elements), human ERVs are capable of retrotransposition in an autonomous manner. In contrast, short interspersed nuclear elements (SINEs) like ALU or MIR (mammalian-wide interspersed repeats) sequences cannot perform autonomous retrotransposition. Nevertheless, ALU sequences may be able to move with the help of active LINE elements

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