Fig. 5
From: Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3
pS727-STAT3 stimulation preserves mitochondrial bioenergetics against FAK inhibition. a Bryostatin and HGF preserved reserve and respiratory capacity in bEnd5 cells incubated with FAK14 (5 μM, F5) for 4 h. Data are mean ± SEM from 3 independent experiments. *p < 0.05, **p < 0.01, **p < 0.001. b Western blots of whole cell lysates showing that bryostatin (BST) and HGF preserve pS727-STAT3 in the presence of FAK14 (representative for 3 independent experiments). c Bryostatin does not affect the mitochondrial bioenergetics dysfunction caused by STAT3 inhibition with stattic. N = 3