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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: GPR91: expanding the frontiers of Krebs cycle intermediates

Fig. 3

Succinate role in the liver through GPR91. During an ischemic condition, succinate is released by anoxic hepatocytes and binds to stellate cells leading to their activation. Once activated, stellate cells increase expression of several fibrogenic markers, such as alpha-smooth muscle actin (α-sma), TGF-B and collagen type I

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Cell Communication and Signaling

ISSN: 1478-811X