Fig. 5
From: Hydrogen peroxide – production, fate and role in redox signaling of tumor cells
Trx-based upregulation of anti-oxidative systems by Nrf2. Oxidized Trxs are reduced by TrxRs and maintained in their active form. Reduced Trxs can reduce oxidized Prxs, which under physiological conditions detoxify H2O2. Reduced Trxs can interact with redox-sensitive proteins, such as ASK1, PTEN, AP-1 and p53 suggesting that different cellular processes such as proliferation, the cellular metabolism and apoptosis and might be regulated by Trxs.