Gastric cancer stem cells induced by H. pylori infection-induced autophagy Go Yoshida, Tokyo Medical and Dental University 30 July 2015 Vacuolating cytotoxin A (VacA) in H. pylori-infected gastric cells increases reactive oxygen species (ROS) and induce conventional autophagy, thereby promoting the degradation of PAI-encoded cytotoxin-associated gene A (CagA) protein. Decreased CagA prevents tumorigenesis by inhibiting Src/MEK/ERK signaling activation. CD44 variant 8-10 (CD44v)-expressing gastric cells have enhanced anti-ROS machinery via the stabilization of xCT cysteine transporter at the cellular membrane. This CD44v-xCT-glutathione axis results in the accumulation of CagA, which is why CD44v-positive cells are potential gastric tumor-initiating cells. Reference; Cell Host & Microbe, 12, 764-777 (2012) Competing interests There are no competing interests to be addressed.