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Fig. 10 | Cell Communication and Signaling

Fig. 10

From: Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells

Fig. 10

Proposed model of CDCA-induced cellular responses in pancreatic duct cells. CDCA acting on the plasma cell membrane induces ATP release via non-vesicular releasing mechanisms (pannexin, connexin, P2X7R, other ion channels) and vesicular exocytosis of ATP. Released ATP may in turn activate P2X receptors/cation channels and P2Y receptors, which allow Ca2+ influx directly (P2XR) or via G-protein coupled signalling mediate Ca2+ release from intracellular stores and Ca2+ influx (P2YR). Furthermore, CDCA may activate TGR5 receptor, which leads to stimulation of adenylyl cyclase and cAMP production, possibly increase in Ca2+ in some cells by yet undefined mechanisms. The sodium-calcium exchanger (NCX) can be stimulated by TGR5 resulting of transport of Ca2+ out of the cell, or into the cell, depending on prevailing electrochemical gradients

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