Figure 7

Characteristic morphological features of HHT-enhanced TRAIL-induced necroptosis and apoptosis in tumor cells. Cells were stimulated as indicated in the legend to Figure 2. Micrographs are showing the morphology of cells after 24 h of treatment (to have a direct comparison to the other performed experiments) as indicated on the left. In each micrograph, two typical morphologies of TRAIL-induced necroptosis (white arrows) and apoptosis (black arrows) are indicated. In Pt45P1 cells, no necroptosis was visible as these cells are resistant to this type of cell death. These cells were used as an additional control to monitor if HHT/CHX treatment results in morphological changes of the cells not related to cell death. Scale bar: 100 μm.