Figure 4
From: Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis
Proposed relationship between MCPyV and mutated precursor LCs in LCH-risk organ (RO) (−). Mutated LCH precursor cells (mutant LC precursors) in peripheral tissues recognize MCPyV and induce LCH-RO (−). LCH lesion is consisted by accumulation and prolonged survival of LCH cells with T cells, eosinophils, macrophages, etc. In LCH lesions the prominent sources of cytokine storm are T cells and LCH cells. LCH cells produce pro-inflammatory cytokines such as IL-1, anti-inflammatory cytokines such as IL-10, and growth factors. After accumulation and prolonged survival of LCH cells, LCH lesions diminish and spontaneous healing may be observed.