Figure 1
From: Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis
Langerhans cells and Merkel cells in the epidermis. (A) Skin of one-year-old female baby with nevus cell nevus. (Hematoxylin and Eosin (H&E) stain). (B) Immunohistochemistry shows S100+ immature Langerhans cell (LC; red), nevus cell (NC; red), and cytokeratin 20 (CK20) + Merkel cells (MC; brown). Same area of panel A. (C) S100+ immature LC and NC (red) and CK20+ MC (brown) in a hair follicle. High power view of the left central part of panel B. (D) Immunohistochemistry shows CD1a + LC (blue) and CD1a- NC. Brown pigments correspond to melanin. Same area of panel A. (E) Immature LCs in the epidermis. High power view of panel D. (F) Immature LCs in a hair follicle are positive for CD1a, while the NCs are negative for CD1a. High power view of panel D.