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Figure 8 | Cell Communication and Signaling

Figure 8

From: Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells

Figure 8

Working model of CNGA1-associated PI3Kγ activation. The CNG channel is localized to the plasma membrane of the rod photoreceptor cells. We propose that the RA-domain of PI3Kγ associates with the RLD-domain of CNGA1, and it will thereby have a close proximity to its substrates. PI3Kγ-generated PIs activate the downstream effectors and thereby regulate various aspects of photoreceptor functions.

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