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Figure 5 | Cell Communication and Signaling

Figure 5

From: Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism

Figure 5

TGF-β1 Is Expressed on CML Exosomes. (a) Western blot analysis shows that LAMA84-derived exosomes express TGF- β1. Loading was based on equal protein amount (upper panel). LAMA84 cells express TGF- β1 receptor (lower panel). (b) After 72 or 96 hours of treatment of LAMA84 with 10 μg/ml of LAMA84-exosomes there is an increase in the phosphorylation of the downstream target of TGF-β1, SMAD 2/3; the treatment does not alter the total level of the protein.

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