From: Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling
sAB | k on (M −1  s −1 ) a | k off (s −1 ) a | K D (nM) a | Loop sequence | |||
---|---|---|---|---|---|---|---|
L3 b | H1 b | H2 b | H3 b | ||||
A-4 | No binding | HYTTPP | FYSSYI | YIYPSYGY | SYYSYYGWDYHNSSGAM | ||
A-8 | 9.6 × 104 | 5.4 × 10−4 | 5.6 | YYSYYYPF | FSSSSM | YISPYYGS | SYGYVYWNAYSSGM |
A-9 | 1.4 × 104 | 3.4 × 10−5 | 2.5 | YSSSYLL | FSSSSI | SIYSYYSS | SYDSYPWVYSYTVSGAF |
A-10 | 1.2 × 105 | 2.6 × 10−3 | 21 | HYTTPP | FSSSYI | SISPYYGS | SYYYPEETAF |